The Partial Molar Isothermal Compressions of the Nucleosides Adenosine, Cytidine, and Uridine in Aqueous Solution at T = (288.15 and 313.15) K

Sound speeds have been measured for aqueous solutions of the nucleosides adenosine, cytidine, and uridine at T = (288.15 and 313.15) K and at ambient pressure. The partial molar isentropic compressions at infinite dilution, K S , 2 o , were derived from the speed of sound data. The partial molar heat capacities at infinite dilution, C p , 2 o , for the three nucleosides at T = (288.15 and 313.15) K were also determined. These K S , 2 o and C p , 2 o results, along with partial molar isobaric expansions at infinite dilution, E 2 o = ( ∂ V 2 o / ∂ T ) p , that were derived using data from the literature, were used to evaluate the partial molar isothermal compressions at infinite dilution, K T , 2 o { K T , 2 o = - ( ∂ V 2 o / ∂ p ) T } , for the nucleosides. The K T , 2 o results were rationalized in terms of nucleoside hydration and its temperature dependence.