Effect of nano-hydroxyapatite toothpaste on microhardness of artificial carious lesions created on extracted teeth

[...]some concerns have been expressed about fluorosis and total fluoride intake.3,4 In recent years, fluoride alternatives have been proposed, including CPP-ACP and nano-hydroxyapatite (NHA) because of their anticariogenic characteristics.5,6 HA contains calcium and phosphate crystals that are found in cementum, enamel and dentin. Because of similar characteristics to human hard tissue, biocompatibility and low solubility in humid environments, HA has received great attention in medicine, dentistry and biology. Results Based on Kolmogorov-Smirnov test, data were distributed normally in all the groups at all the time intervals with minimum probability of 0.345. [...]for the comparison of the two groups after controlling for the effect of hardness variables before and after the intervention (Table 1), ANOVA was applied.