Simple, Efficient, and Convenient One‐Pot Synthesis of Imidazole Derivatives in the Presence of Nanosilica‐supported Imidazolium Ionic Liquid as a Catalyst

An efficient and simple synthesis of 2,4,5‐trisubstituted imidazoles is achieved by three‐component cyclocondensation of benzil, aldehyde, and ammonium acetate by using nanosilica‐supported imidazolium ionic liquid as a catalyst under solvent‐free conditions. The key advantages of this process are high to excellent yields, short reaction time, easy work‐up, and the reusability of the catalyst. An efficient and convenient synthesis of 2,4,5‐trisubstituted imidazoles is attained by three‐component reaction of benzil, aldehyde, and ammonium acetate in the presence of nanosilica‐supported imidazolium ionic liquid as a catalyst under solvent‐free conditions. Highlights are high to excellent yields, short reaction times, easy work‐up, and a recyclable catalyst.