Synthesis of substituted 2-(thiophen-2-yl)-1H-imidazol-1-ols

Synthesis of substituted 2-(thiophen-2-yl)-1H-imidazol-1-ols

Substituted 2-(thiophen-2-yl)-1 H -imidazol-1-ols were synthesized by cyclization of the corresponding α-thienyl nitrones in alkaline medium. α-Thienyl nitrones were obtained by reaction of N -(1-hydroxyimine-1-R-propan-2-yl)hydroxylamines with thiophene-2-carbaldehyde in methanol. At boiling α-thie...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Russian journal of organic chemistry 2017, Vol.53 (2), p.236-239
Hauptverfasser: Os’kina, I. A., Tikhonov, A. Ya
Format: Artikel
Sprache:eng
Schlagworte:
Chemical synthesis
Chemistry
Chemistry and Materials Science
Methanol
Organic Chemistry
Substitutes
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Substituted 2-(thiophen-2-yl)-1 H -imidazol-1-ols were synthesized by cyclization of the corresponding α-thienyl nitrones in alkaline medium. α-Thienyl nitrones were obtained by reaction of N -(1-hydroxyimine-1-R-propan-2-yl)hydroxylamines with thiophene-2-carbaldehyde in methanol. At boiling α-thienyl nitrones in methanol in the presence of sodium methylate 5-aryl(hetaryl)-2-(thiophen-2-yl)-1 H -imidazol-1-ols are formed chemoselectively.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428017020166