Ultra-high-performance liquid chromatography tandem mass spectrometry determination of GHB, GHB-glucuronide in plasma and cerebrospinal fluid of narcoleptic patients under sodium oxybate treatment

Highlights • UHPLC-MS/MS assay for plasma and CSF GHB and GHB-Gluc in narcoleptic patients • GHB plasma values increased disproportionally with rising Xyrem® dose • Plasma GHB-Gluc concentration did not change with increasing Xyrem® dose • Disproportional CSF GHB concentrations were observed with in...

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Veröffentlicht in:	Forensic science international 2017-05, Vol.274, p.70-74
Hauptverfasser:	Tittarelli, Roberta, Pichini, Simona, Pedersen, Daniel S, Pacifici, Roberta, Moresco, Monica, Pizza, Fabio, Busardò, Francesco Paolo, Plazzi, Giuseppe
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Adolescent Adult Cataplexy Central Nervous System Depressants - administration & dosage Central Nervous System Depressants - blood Central Nervous System Depressants - cerebrospinal fluid Cerebrospinal fluid Chromatography Chromatography, High Pressure Liquid Daytime Dose-Response Relationship, Drug Drug dosages FDA approval Forensic sciences GHB GHB glucuronide Glucuronides - blood Glucuronides - cerebrospinal fluid High performance liquid chromatography Humans Laboratories Liquid chromatography Male Mass spectrometry Mass spectroscopy Middle Aged Narcolepsy Narcolepsy - drug therapy Neurotrophin 1 Nonlinear response Orexins Pathology Patients Pharmacokinetics Pharmacology Plasma pharmacokinetics Plasmas (physics) Salts Scientific imaging Sleep Sleep and wakefulness Sleep disorders Sleepiness Sodium Sodium Oxybate - administration & dosage Sodium Oxybate - blood Sodium Oxybate - cerebrospinal fluid Solvents Spectroscopy Tandem Mass Spectrometry Therapeutic drug monitoring Ultra-high performance liquid chromatography tandem mass spectrometry Urine γ-Hydroxybutyric acid
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Beschreibung
Zusammenfassung:	Highlights • UHPLC-MS/MS assay for plasma and CSF GHB and GHB-Gluc in narcoleptic patients • GHB plasma values increased disproportionally with rising Xyrem® dose • Plasma GHB-Gluc concentration did not change with increasing Xyrem® dose • Disproportional CSF GHB concentrations were observed with increasing Xyrem® dose • GHB-Gluc in CSF samples was not detectable in treated patients and controls
ISSN:	0379-0738 1872-6283
DOI:	10.1016/j.forsciint.2017.01.015