Addition of Primary Amines to 2‐(1‐Alkynyl)‐2‐cycloalken‐1‐ones
The regio‐ and stereoselective nucleophilic addition of primary aliphatic amines to 2‐(1‐alkynyl)‐2‐alken‐1‐ones was found to proceed through double‐bond migration. In particular, this is a mild and atom‐economical route for the preparation of (Z)‐β‐enaminones having cycloalkene rings. The regio‐ an...
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Veröffentlicht in: | European journal of organic chemistry 2017-03, Vol.2017 (12), p.1624-1627 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The regio‐ and stereoselective nucleophilic addition of primary aliphatic amines to 2‐(1‐alkynyl)‐2‐alken‐1‐ones was found to proceed through double‐bond migration. In particular, this is a mild and atom‐economical route for the preparation of (Z)‐β‐enaminones having cycloalkene rings.
The regio‐ and stereoselective nucleophilic addition of primary aliphatic amines to 2‐(1‐alkynyl)‐2‐cycloalken‐1‐ones proceeds through double‐bond migration. In particular, (Z)‐β‐enaminones having cycloalkene rings can be prepared through a mild and atom‐economical route. |
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ISSN: | 1434-193X 1099-0690 |
DOI: | 10.1002/ejoc.201700119 |