Acyclovir Treatment of the Chronic Fatigue Syndrome

Twenty-seven adults with a diagnosis of the chronic fatigue syndrome were enrolled in a double-blind, placebo-controlled study of acyclovir therapy. The patients had had debilitating fatigue for an average of 6.8 years, accompanied by persisting antibodies to Epstein–Barr virus early antigens (titer...

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Veröffentlicht in:	The New England journal of medicine 1988-12, Vol.319 (26), p.1692-1698
Hauptverfasser:	Straus, Stephen E, Dale, Janet K, Tobi, Martin, Lawley, Thomas, Preble, Olivia, Blaese, R. Michael, Hallahan, Claire, Henle, Werner
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyclovir Antibodies Antigen-antibody complexes Antigens Antiviral drugs Chronic fatigue syndrome Clinical trials Disease control Epstein-Barr virus Fatigue Immunoglobulins Infectious diseases Intravenous administration Laboratories Lymphatic system Mood Patients Placebos Remission Thyroid gland Virology Viruses
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Beschreibung
Zusammenfassung:	Twenty-seven adults with a diagnosis of the chronic fatigue syndrome were enrolled in a double-blind, placebo-controlled study of acyclovir therapy. The patients had had debilitating fatigue for an average of 6.8 years, accompanied by persisting antibodies to Epstein–Barr virus early antigens (titers ≥1:40) or undetectable levels of antibodies to Epstein–Barr virus nuclear antigens (titers
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJM198812293192602