A Convenient and Efficient Palladium‐Catalyzed Carbonylative Sonogashira Transformation with Formic Acid as the CO Source

A practical, convenient, and efficient palladium‐catalyzed carbonylative Sonogashira reaction of aryl iodides was developed. With formic acid as the CO source and dicyclohexylcarbodiimide as the activator, various alkynones were produced in good to excellent yields. See you, CO! A convenient and efficient gaseous CO‐free carbonylative Sonogashira reaction is developed. By employing formic acid as the CO source and dicyclohexylcarbodiimide (DCC) as the activator, synthetically useful alkynones are produced in good to excellent yields. Tedious pre‐preparation steps and the use of large excess amounts of reagents can be successfully avoided.