PLGA encapsulation effect on Bioquin-HMPAO: radiolabeling and in vitro behaviour on brain and lung cancer cells

PLGA encapsulation effect on Bioquin-HMPAO: radiolabeling and in vitro behaviour on brain and lung cancer cells

Bioquin-HMPAO (BH) was previously investigated as a novel brain imaging agent by in vivo biodistribution studies. Present studies are carried out to explore radiolabeling and in vitro behaviour evaluation of poly (lactic-co-glycolic acid) (PLGA) encapsulated BH nanocapsules (BH-PLGA NCs). BH-PLGA NC...

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Veröffentlicht in:Journal of radioanalytical and nuclear chemistry 2016-10, Vol.310 (1), p.155-164
Hauptverfasser: Yurt Kilcar, Ayfer, Biber Muftuler, F. Zumrut, Medine, E. Ilker, Tekin, Volkan
Format: Artikel
Sprache:eng
Schlagworte:
Brain
Brain research
Chemistry
Chemistry and Materials Science
Diagnostic Radiology
Encapsulation
Glycolic acid
Hadrons
Heavy Ions
In vivo methods and tests
Inorganic Chemistry
Lung cancer
Nuclear Chemistry
Nuclear Physics
Photon correlation spectroscopy
Physical Chemistry
Radiation measurement
Radiolabelling
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Zusammenfassung:Bioquin-HMPAO (BH) was previously investigated as a novel brain imaging agent by in vivo biodistribution studies. Present studies are carried out to explore radiolabeling and in vitro behaviour evaluation of poly (lactic-co-glycolic acid) (PLGA) encapsulated BH nanocapsules (BH-PLGA NCs). BH-PLGA NCs were characterized utilizing dynamic light scattering and scanning electron microscope. Encapsulation effect on radiolabeling with 99m Tc was examined by stability and lipophilicity studies and effect on in vitro behaviour of 99m Tc-BH was evaluated by incorporation studies on DAOY, U87-MG and A549 cells. It is observed that PLGA encapsulation has a positive and reinforcement effect.
ISSN:0236-5731
1588-2780
DOI:10.1007/s10967-016-4746-0