Associates of thioalkyl derivatives of 2-arylaminopyrimidine with hydroxyapatite-based nanocomposites

Co-precipitation and ultrasonic treatment methods have been used for the in situ formation of the composites of hydroxyapatite (HA) covered with nanoparticles of magnetite as well as compositions of magnetite, gold and silver. The thioalkyl-substituted derivatives of 2-arylaminopyrimidine, structura...

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Veröffentlicht in:Russian journal of general chemistry 2016-08, Vol.86 (8), p.1886-1895
Hauptverfasser: Eryomin, A. N., Pietkievich, A. V., Abakshonok, A. V., Siniutsich, Yu. V., Ignatovich, Zh. V., Agabekov, V. E., Al-Muhanna, M. K.
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container_end_page 1895
container_issue 8
container_start_page 1886
container_title Russian journal of general chemistry
container_volume 86
creator Eryomin, A. N.
Pietkievich, A. V.
Abakshonok, A. V.
Siniutsich, Yu. V.
Ignatovich, Zh. V.
Agabekov, V. E.
Al-Muhanna, M. K.
description Co-precipitation and ultrasonic treatment methods have been used for the in situ formation of the composites of hydroxyapatite (HA) covered with nanoparticles of magnetite as well as compositions of magnetite, gold and silver. The thioalkyl-substituted derivatives of 2-arylaminopyrimidine, structural analogs of antitumor drug Imatinib containing one or two SH groups and capable to chemisorption on hydroxyapatite and its nanocomposites, have been synthesized. Two-component Fe 3 O 4 (HA) and three-component Fe 3 O 4 (HA)Au and Fe 3 O 4 (HA)Ag composites have been found the most promising as nanocarriers of bioactive compounds.
doi_str_mv 10.1134/S1070363216080181
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source Springer Nature - Complete Springer Journals
subjects Chemisorption
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Hydroxyapatite
Iron oxides
Magnetite
Nanocomposites
Particulate composites
Silver
Ultrasonic processing
title Associates of thioalkyl derivatives of 2-arylaminopyrimidine with hydroxyapatite-based nanocomposites
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