New derivatives of 1,3,4-thiadiazole based on hydrazide of 3-methoxyphenoxyacetic acid

New derivatives of 1,3,4-thiadiazole based on hydrazide of 3-methoxyphenoxyacetic acid

2-Substituted 1,3,4-thiadiazole-5-thiol has been synthesized basing on hydrazide of 3-methoxy-phenoxyacetic acid. Methods of SH-alkylation, aminomethylation, and cyanoethylation of the product have been elaborated. Reactions of the starting hydrazide leading to 4-amino-3,5-substituted 4 Н -1,2,4-tri...

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Veröffentlicht in:Russian journal of general chemistry 2016-08, Vol.86 (8), p.1845-1849
Hauptverfasser: Hovsepyan, T. R., Hakobyan, M. R., Minasyan, N. S., Melik-Ohanjanyan, R. G.
Format: Artikel
Sprache:eng
Schlagworte:
Alkylation
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Cyanoethylation
Dicarboxylic acids
Hydrazides
Substitutes
Thiadiazoles
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Zusammenfassung:2-Substituted 1,3,4-thiadiazole-5-thiol has been synthesized basing on hydrazide of 3-methoxy-phenoxyacetic acid. Methods of SH-alkylation, aminomethylation, and cyanoethylation of the product have been elaborated. Reactions of the starting hydrazide leading to 4-amino-3,5-substituted 4 Н -1,2,4-triazoles and acyl hydrazides of dicarboxylic acids containing pharmacophore groups in the molecule have been studied.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363216080119