Comparative enzyme inhibition study of 1-deazapurines

A series of nitrogen heterocycles including the derivatives of 1-deazapurines, were studied for miscellaneous enzyme inhibition activities in search of the potent enzyme inhibitor. The hyperactive enzymes like carbonic anhydrase-II, phosphodiesterase-I, xanthine oxidase, α -glucosidase, and β-glucuronidase were selected for the study. The compounds 1 , 2 , 3 , 6 , 8 , 11 – 13 and 15 – 17 , showed significant and selective activities against different enzymes. The compounds 11 and 12 were found the most potent against carbonic anhydrase-II, α -glucosidase and β-glucuronidase in comparison to their standard compounds. These selective inhibitors can be used as lead compounds for development of drugs against various diseases associated with these enzymes.