A study of the viscosity of hyaluronic acid solutions for the preparation of polyelectrolyte complexes with chitosan

A study of the viscosity of hyaluronic acid solutions for the preparation of polyelectrolyte complexes with chitosan

The viscosity of hyaluronic acid solutions kept at different pH values was found to decrease in the following order of pH: 6.5 > 3.5 > 4.3, although acid hydrolysis occurred at a higher rate in the most acidic solution. The poorest stability of the solutions with pH 4.3 was attributed to the c...

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Veröffentlicht in:Russian chemical bulletin 2016, Vol.65 (1), p.273-276
Hauptverfasser: Uspenskii, S. A., Kil’deeva, N. R., Maslova, M. V., Demina, T. S., Vikhoreva, G. A.
Format: Artikel
Sprache:eng
Schlagworte:
Charge density
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Chitosan
Full Articles
Hyaluronic acid
Inorganic Chemistry
Macromolecules
Organic Chemistry
Polyacids
Polyelectrolytes
Viscosity
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Zusammenfassung:The viscosity of hyaluronic acid solutions kept at different pH values was found to decrease in the following order of pH: 6.5 > 3.5 > 4.3, although acid hydrolysis occurred at a higher rate in the most acidic solution. The poorest stability of the solutions with pH 4.3 was attributed to the compaction of the macromolecules as a result of charge density redistribution along the polyacid chains.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-016-1296-0