Synthesis and evaluation of the influence of 5-sulfanyl-1,2,3-triazol-1-ylaminocarboxylic acid derivatives on kinetics of ascorbic acid oxidation

1,2,3-Thiadiazolylureas containing amino acid residues were synthesized. These compounds were converted to 5-sulfanyl-1,2,3-triazol-1-ylaminocarboxylic acid sodium salts under alkaline conditions. These salts were found to inhibit the oxidation of ascorbic acid with air oxygen. In the presence of the equimolar amount of 5-sulfanyl-1,2,3-triazoles, the rate of diminution of ascorbic acid decreased by 1.5—3 times, whereas in the case of their two-fold excess by a factor of 5.