Synthesis of 4-aryl-1,7-dihydroxyalkane-2,6-diones under aldol reaction conditions

Reactions of 3-hydroxyalkan-2-ones with (hetero)aromatic aldehydes under basic conditions lead to 4-aryl-1,7-dihydroxyalkane-2,6-diones. These products were also synthesized by dismutation of 4-aryl-1-hydroxyalk-3-ene-2-ones. The reactions proceed as tandem retro aldol reactions and the Michael addi...

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Veröffentlicht in:	Russian chemical bulletin 2016-03, Vol.65 (3), p.714-720
1. Verfasser:	Mavrov, M. V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes Aromatic compounds Cascade chemical reactions Chemical synthesis Chemistry Chemistry and Materials Science Chemistry/Food Science Diketones Full Articles Inorganic Chemistry Organic Chemistry
Online-Zugang:	Volltext
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Zusammenfassung:	Reactions of 3-hydroxyalkan-2-ones with (hetero)aromatic aldehydes under basic conditions lead to 4-aryl-1,7-dihydroxyalkane-2,6-diones. These products were also synthesized by dismutation of 4-aryl-1-hydroxyalk-3-ene-2-ones. The reactions proceed as tandem retro aldol reactions and the Michael addition.
ISSN:	1066-5285 1573-9171
DOI:	10.1007/s11172-016-1361-8