Synthesis of novel 1, 2, 4-triazolopyrimidines and their evaluation as antimicrobial agents

Synthesis of novel 1, 2, 4-triazolopyrimidines and their evaluation as antimicrobial agents

7-aminopyrimidin-5(1 H )-one (5) was utilized as a starting material for the preparation of new, Schiff bases ( 13 – 19 ), amides 23 , 24 , imide 25 , as well as thiourea derivatives 30 – 33 incorporating the triazolopyrimidines nucleus in their molecules. Structural elucidations for the new compoun...

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Veröffentlicht in:Medicinal chemistry research 2017, Vol.26 (1), p.120-130
Hauptverfasser: Abu-Hashem, Ameen A., Hussein, Hoda A. R., Abu-zied, Khadeja M.
Format: Artikel
Sprache:eng
Schlagworte:
Amides
Antimicrobial agents
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Original Research
Pharmacology/Toxicology
Thiourea
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Zusammenfassung:7-aminopyrimidin-5(1 H )-one (5) was utilized as a starting material for the preparation of new, Schiff bases ( 13 – 19 ), amides 23 , 24 , imide 25 , as well as thiourea derivatives 30 – 33 incorporating the triazolopyrimidines nucleus in their molecules. Structural elucidations for the new compounds were based upon compatible microanalytical and spectroscopic measurement. Biological evaluation indicated that compounds 23 , 31 , 33 , 32 , and 30 possess promising antimicrobial activities. Graphical Abstract
ISSN:1054-2523
1554-8120
DOI:10.1007/s00044-016-1733-5