Two Metal–Organic Frameworks with Pharmaceutical Ingredient Linker: Influence of pH and Temperature

Two new metal–organic frameworks of [Zn 3 (bdc) 2 (dfp) 2 ]·2DMF ( 1 ) and [Zn 3 (bdc-NH 2 ) 2 (dfp) 2 ]·DMF ( 2 ) (H 2 bdc = 1,4-benzenedicarboxylic acid, H 2 bdc-NH 2 = 2-amino-1,4-benzenedicarboxylic acid and Hdfp = deferiprone) have been used as matrices for the drug carrier of 5-fluorouracil (5-FU). Drug loading content and drug release behavior of 1–2 were studied. These results indicate that their adsorption capacities for 5-FU were 38.4 and 35.9 wt% for 1 and 2 , respectively. The drug release behaviors of 1–2 at different pH values (40, 6.0 and 7.4) and different temperature (37 and 40 °C) were investigated. A structure-activity relationship strategy has been conducted with the aim of rationalizing the experimental drug uptakes and emphasizing the relevant chemical and structural features that significantly impact their encapsulation and releasing performances in 1–2 . Graphical Abstract A structure-activity relationship strategy has been conducted with the aim of rationalizing the experimental drug uptakes and emphasizing the relevant chemical and structural features that significantly impact their encapsulation and releasing performances in 1–2 .