Potential synthetic adaptogens 1. Synthesis and studies of new N-[(adamantan-1-yl)methyl]aniline derivatives based on adamantane-1-carbaldehyde

Potential synthetic adaptogens 1. Synthesis and studies of new N-[(adamantan-1-yl)methyl]aniline derivatives based on adamantane-1-carbaldehyde

A number of new N -[(adamantan-1-yl)methyl]aniline derivatives, which can be considered as conformationally labile analogues of synthetic adaptogen Bromantan, were obtained by the reductive amination reaction of adamantane-1-carbaldehyde with aromatic amines. The influence of the reaction conditions...

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Veröffentlicht in:Russian chemical bulletin 2016-05, Vol.65 (5), p.1336-1340
Hauptverfasser: Voloboev, S. N., Andreev, A. V., Mkrtchyan, A. S., Navrotskii, M. B., Novakov, I. A., Orlinson, B. S., Son, V. V.
Format: Artikel
Sprache:eng
Schlagworte:
Adaptogens
Amines
Aniline
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Derivatives
Full Articles
Inorganic Chemistry
Organic Chemistry
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Zusammenfassung:A number of new N -[(adamantan-1-yl)methyl]aniline derivatives, which can be considered as conformationally labile analogues of synthetic adaptogen Bromantan, were obtained by the reductive amination reaction of adamantane-1-carbaldehyde with aromatic amines. The influence of the reaction conditions of reductive amination on the yield and composition of its products was studied.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-016-1458-0