Synthesis of spiro[imidazole-2,2′-pyrroles] by reaction of 4,5-dioxo-4,5-dihydro-1H-pyrrole-2-carboxylates with urea

Synthesis of spiro[imidazole-2,2′-pyrroles] by reaction of 4,5-dioxo-4,5-dihydro-1H-pyrrole-2-carboxylates with urea

Substituted alkyl 4,5-dioxo-4,5-dihydro-1 H -pyrrole-2-carboxylates reacted with urea to give alkyl 2-(carbamoylamino)-4-hydroxy-5-oxo-2,5-dihydro-1 H -pyrrole-2-carboxylates which underwent intramolecular cyclization to 8-hydroxy-1,3,6-triazaspiro[4.4]non-8-ene-2,4,7-triones by the action of sodium...

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Veröffentlicht in:Russian journal of organic chemistry 2016, Vol.52 (12), p.1779-1783
Hauptverfasser: Dubovtsev, A. Yu, Silaichev, P. S., Zheleznova, M. A., Aliev, Z. G., Maslivets, A. N.
Format: Artikel
Sprache:eng
Schlagworte:
Carboxylates
Chemical synthesis
Chemistry
Chemistry and Materials Science
Imidazole
Organic Chemistry
Pyrroles
Ureas
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Zusammenfassung:Substituted alkyl 4,5-dioxo-4,5-dihydro-1 H -pyrrole-2-carboxylates reacted with urea to give alkyl 2-(carbamoylamino)-4-hydroxy-5-oxo-2,5-dihydro-1 H -pyrrole-2-carboxylates which underwent intramolecular cyclization to 8-hydroxy-1,3,6-triazaspiro[4.4]non-8-ene-2,4,7-triones by the action of sodium methoxide.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428016120113