Sodium butyrate enhances the antiproliferative action of low actinomycin D concentrations

Sodium butyrate enhances the antiproliferative action of low actinomycin D concentrations

Histone deacetylase inhibitors (HDIs) cause an irreversible cell cycle arrest in G 1 phase and senescence of E1A + Ras transformed fibroblasts. The modulation of the antiproliferative action of the RNA synthesis inhibitor actinomycin D (AMD) with sodium butyrate (NaBut) has been studied. It is shown...

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Veröffentlicht in:Cell and tissue biology 2017, Vol.11 (1), p.42-50
Hauptverfasser: Igotti, M. V., Gnedina, O. O., Svetlikova, S. B., Filippova, E. A., Pospelov, V. A.
Format: Artikel
Sprache:eng
Schlagworte:
Biomedical and Life Sciences
Cell Biology
Life Sciences
Oncogenes
p53 Protein
Tumors
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Zusammenfassung:Histone deacetylase inhibitors (HDIs) cause an irreversible cell cycle arrest in G 1 phase and senescence of E1A + Ras transformed fibroblasts. The modulation of the antiproliferative action of the RNA synthesis inhibitor actinomycin D (AMD) with sodium butyrate (NaBut) has been studied. It is shown that NaBut enhances the cytotoxic effect of low AMD concentrations (
ISSN:1990-519X
1990-5203
DOI:10.1134/S1990519X17010059