Tris(2,6-dimethoxyphenyl)methyl carbenium ion as a charge derivatization agent for the analysis of primary amines by MALDI mass spectrometry
A novel derivatization method for the analysis of primary amines by MALDI mass spectrometry is proposed. Tris(2,6-dimethoxyphenyl) methyl carbenium cation reacts smoothly with primary amines, forming permanently charged adducts with the mass increment +359 Da and absorbance in the UV region. The app...
Gespeichert in:
| Veröffentlicht in: | Journal of analytical chemistry (New York, N.Y.) N.Y.), 2016-12, Vol.71 (14), p.1326-1331 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1331 |
|---|---|
| container_issue | 14 |
| container_start_page | 1326 |
| container_title | Journal of analytical chemistry (New York, N.Y.) |
| container_volume | 71 |
| creator | Topolyan, A. P. Strizhevskaya, D. A. Slyundina, M. S. Belyaeva, M. A. Ivanova, O. M. Korshun, V. A. Ustinov, A. V. Mikhura, I. V. Formanovsky, A. A. Borisov, R. S. |
| description | A novel derivatization method for the analysis of primary amines by MALDI mass spectrometry is proposed. Tris(2,6-dimethoxyphenyl) methyl carbenium cation reacts smoothly with primary amines, forming permanently charged adducts with the mass increment +359 Da and absorbance in the UV region. The approach was tested on a number of amines, including biologically active compounds and therapeutic agents. |
| doi_str_mv | 10.1134/S106193481614015X |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1880772678</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1880772678</sourcerecordid><originalsourceid>FETCH-LOGICAL-c316t-e06e1c156e398df0c0461762f038b5912dade64b9c497331d50a8af2d934f9f03</originalsourceid><addsrcrecordid>eNp1kMtKxDAUhosoOI4-gLuAGwWrOb2kzXIYbwMjLhzBXUnTk2mG3kw6Yn0GH9qUcSGIi5Ac_u__T87xvFOgVwBhdP0MlAEPoxQYRBTi1z1vAoymfgic77u3k_1RP_SOrN1QSrlDJ97Xymh7Hlwyv9A19mX7MXQlNkN1MVZDRaQwOTZ6WxPdNkRYIogshVkjKdDod9HrT3dGaY1NT1RrSF8iEY2oBqstaRXpjK6FGYiodYOW5AN5nC1vFqQW1hLboexN67qZ4dg7UKKyePJzT72Xu9vV_MFfPt0v5rOlL0NgvY-UIUiIGYY8LRSVNGKQsEDRMM1jDkEhCmRRzmXEkzCEIqYiFSoo3PyKO2rqne1yO9O-bdH22abdGvdjm0Ga0iQJWJI6CnaUNK21BlX2M0gGNBuXnv1ZuvMEO491bLNG8yv5X9M3cdWFOw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1880772678</pqid></control><display><type>article</type><title>Tris(2,6-dimethoxyphenyl)methyl carbenium ion as a charge derivatization agent for the analysis of primary amines by MALDI mass spectrometry</title><source>Springer Nature - Complete Springer Journals</source><creator>Topolyan, A. P. ; Strizhevskaya, D. A. ; Slyundina, M. S. ; Belyaeva, M. A. ; Ivanova, O. M. ; Korshun, V. A. ; Ustinov, A. V. ; Mikhura, I. V. ; Formanovsky, A. A. ; Borisov, R. S.</creator><creatorcontrib>Topolyan, A. P. ; Strizhevskaya, D. A. ; Slyundina, M. S. ; Belyaeva, M. A. ; Ivanova, O. M. ; Korshun, V. A. ; Ustinov, A. V. ; Mikhura, I. V. ; Formanovsky, A. A. ; Borisov, R. S.</creatorcontrib><description>A novel derivatization method for the analysis of primary amines by MALDI mass spectrometry is proposed. Tris(2,6-dimethoxyphenyl) methyl carbenium cation reacts smoothly with primary amines, forming permanently charged adducts with the mass increment +359 Da and absorbance in the UV region. The approach was tested on a number of amines, including biologically active compounds and therapeutic agents.</description><identifier>ISSN: 1061-9348</identifier><identifier>EISSN: 1608-3199</identifier><identifier>DOI: 10.1134/S106193481614015X</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Adducts ; Amines ; Analytical Chemistry ; Chemistry ; Chemistry and Materials Science ; Mass spectrometry ; Pharmacology</subject><ispartof>Journal of analytical chemistry (New York, N.Y.), 2016-12, Vol.71 (14), p.1326-1331</ispartof><rights>Pleiades Publishing, Ltd. 2016</rights><rights>Copyright Springer Science & Business Media 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c316t-e06e1c156e398df0c0461762f038b5912dade64b9c497331d50a8af2d934f9f03</citedby><cites>FETCH-LOGICAL-c316t-e06e1c156e398df0c0461762f038b5912dade64b9c497331d50a8af2d934f9f03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S106193481614015X$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S106193481614015X$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids></links><search><creatorcontrib>Topolyan, A. P.</creatorcontrib><creatorcontrib>Strizhevskaya, D. A.</creatorcontrib><creatorcontrib>Slyundina, M. S.</creatorcontrib><creatorcontrib>Belyaeva, M. A.</creatorcontrib><creatorcontrib>Ivanova, O. M.</creatorcontrib><creatorcontrib>Korshun, V. A.</creatorcontrib><creatorcontrib>Ustinov, A. V.</creatorcontrib><creatorcontrib>Mikhura, I. V.</creatorcontrib><creatorcontrib>Formanovsky, A. A.</creatorcontrib><creatorcontrib>Borisov, R. S.</creatorcontrib><title>Tris(2,6-dimethoxyphenyl)methyl carbenium ion as a charge derivatization agent for the analysis of primary amines by MALDI mass spectrometry</title><title>Journal of analytical chemistry (New York, N.Y.)</title><addtitle>J Anal Chem</addtitle><description>A novel derivatization method for the analysis of primary amines by MALDI mass spectrometry is proposed. Tris(2,6-dimethoxyphenyl) methyl carbenium cation reacts smoothly with primary amines, forming permanently charged adducts with the mass increment +359 Da and absorbance in the UV region. The approach was tested on a number of amines, including biologically active compounds and therapeutic agents.</description><subject>Adducts</subject><subject>Amines</subject><subject>Analytical Chemistry</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Mass spectrometry</subject><subject>Pharmacology</subject><issn>1061-9348</issn><issn>1608-3199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNp1kMtKxDAUhosoOI4-gLuAGwWrOb2kzXIYbwMjLhzBXUnTk2mG3kw6Yn0GH9qUcSGIi5Ac_u__T87xvFOgVwBhdP0MlAEPoxQYRBTi1z1vAoymfgic77u3k_1RP_SOrN1QSrlDJ97Xymh7Hlwyv9A19mX7MXQlNkN1MVZDRaQwOTZ6WxPdNkRYIogshVkjKdDod9HrT3dGaY1NT1RrSF8iEY2oBqstaRXpjK6FGYiodYOW5AN5nC1vFqQW1hLboexN67qZ4dg7UKKyePJzT72Xu9vV_MFfPt0v5rOlL0NgvY-UIUiIGYY8LRSVNGKQsEDRMM1jDkEhCmRRzmXEkzCEIqYiFSoo3PyKO2rqne1yO9O-bdH22abdGvdjm0Ga0iQJWJI6CnaUNK21BlX2M0gGNBuXnv1ZuvMEO491bLNG8yv5X9M3cdWFOw</recordid><startdate>20161201</startdate><enddate>20161201</enddate><creator>Topolyan, A. P.</creator><creator>Strizhevskaya, D. A.</creator><creator>Slyundina, M. S.</creator><creator>Belyaeva, M. A.</creator><creator>Ivanova, O. M.</creator><creator>Korshun, V. A.</creator><creator>Ustinov, A. V.</creator><creator>Mikhura, I. V.</creator><creator>Formanovsky, A. A.</creator><creator>Borisov, R. S.</creator><general>Pleiades Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20161201</creationdate><title>Tris(2,6-dimethoxyphenyl)methyl carbenium ion as a charge derivatization agent for the analysis of primary amines by MALDI mass spectrometry</title><author>Topolyan, A. P. ; Strizhevskaya, D. A. ; Slyundina, M. S. ; Belyaeva, M. A. ; Ivanova, O. M. ; Korshun, V. A. ; Ustinov, A. V. ; Mikhura, I. V. ; Formanovsky, A. A. ; Borisov, R. S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-e06e1c156e398df0c0461762f038b5912dade64b9c497331d50a8af2d934f9f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adducts</topic><topic>Amines</topic><topic>Analytical Chemistry</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Mass spectrometry</topic><topic>Pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Topolyan, A. P.</creatorcontrib><creatorcontrib>Strizhevskaya, D. A.</creatorcontrib><creatorcontrib>Slyundina, M. S.</creatorcontrib><creatorcontrib>Belyaeva, M. A.</creatorcontrib><creatorcontrib>Ivanova, O. M.</creatorcontrib><creatorcontrib>Korshun, V. A.</creatorcontrib><creatorcontrib>Ustinov, A. V.</creatorcontrib><creatorcontrib>Mikhura, I. V.</creatorcontrib><creatorcontrib>Formanovsky, A. A.</creatorcontrib><creatorcontrib>Borisov, R. S.</creatorcontrib><collection>CrossRef</collection><jtitle>Journal of analytical chemistry (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Topolyan, A. P.</au><au>Strizhevskaya, D. A.</au><au>Slyundina, M. S.</au><au>Belyaeva, M. A.</au><au>Ivanova, O. M.</au><au>Korshun, V. A.</au><au>Ustinov, A. V.</au><au>Mikhura, I. V.</au><au>Formanovsky, A. A.</au><au>Borisov, R. S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tris(2,6-dimethoxyphenyl)methyl carbenium ion as a charge derivatization agent for the analysis of primary amines by MALDI mass spectrometry</atitle><jtitle>Journal of analytical chemistry (New York, N.Y.)</jtitle><stitle>J Anal Chem</stitle><date>2016-12-01</date><risdate>2016</risdate><volume>71</volume><issue>14</issue><spage>1326</spage><epage>1331</epage><pages>1326-1331</pages><issn>1061-9348</issn><eissn>1608-3199</eissn><abstract>A novel derivatization method for the analysis of primary amines by MALDI mass spectrometry is proposed. Tris(2,6-dimethoxyphenyl) methyl carbenium cation reacts smoothly with primary amines, forming permanently charged adducts with the mass increment +359 Da and absorbance in the UV region. The approach was tested on a number of amines, including biologically active compounds and therapeutic agents.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S106193481614015X</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1061-9348 |
| ispartof | Journal of analytical chemistry (New York, N.Y.), 2016-12, Vol.71 (14), p.1326-1331 |
| issn | 1061-9348 1608-3199 |
| language | eng |
| recordid | cdi_proquest_journals_1880772678 |
| source | Springer Nature - Complete Springer Journals |
| subjects | Adducts Amines Analytical Chemistry Chemistry Chemistry and Materials Science Mass spectrometry Pharmacology |
| title | Tris(2,6-dimethoxyphenyl)methyl carbenium ion as a charge derivatization agent for the analysis of primary amines by MALDI mass spectrometry |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T15%3A59%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Tris(2,6-dimethoxyphenyl)methyl%20carbenium%20ion%20as%20a%20charge%20derivatization%20agent%20for%20the%20analysis%20of%20primary%20amines%20by%20MALDI%20mass%20spectrometry&rft.jtitle=Journal%20of%20analytical%20chemistry%20(New%20York,%20N.Y.)&rft.au=Topolyan,%20A.%20P.&rft.date=2016-12-01&rft.volume=71&rft.issue=14&rft.spage=1326&rft.epage=1331&rft.pages=1326-1331&rft.issn=1061-9348&rft.eissn=1608-3199&rft_id=info:doi/10.1134/S106193481614015X&rft_dat=%3Cproquest_cross%3E1880772678%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1880772678&rft_id=info:pmid/&rfr_iscdi=true |