Tris(2,6-dimethoxyphenyl)methyl carbenium ion as a charge derivatization agent for the analysis of primary amines by MALDI mass spectrometry

Tris(2,6-dimethoxyphenyl)methyl carbenium ion as a charge derivatization agent for the analysis of primary amines by MALDI mass spectrometry

A novel derivatization method for the analysis of primary amines by MALDI mass spectrometry is proposed. Tris(2,6-dimethoxyphenyl) methyl carbenium cation reacts smoothly with primary amines, forming permanently charged adducts with the mass increment +359 Da and absorbance in the UV region. The app...

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Veröffentlicht in:Journal of analytical chemistry (New York, N.Y.) N.Y.), 2016-12, Vol.71 (14), p.1326-1331
Hauptverfasser: Topolyan, A. P., Strizhevskaya, D. A., Slyundina, M. S., Belyaeva, M. A., Ivanova, O. M., Korshun, V. A., Ustinov, A. V., Mikhura, I. V., Formanovsky, A. A., Borisov, R. S.
Format: Artikel
Sprache:eng
Schlagworte:
Adducts
Amines
Analytical Chemistry
Chemistry
Chemistry and Materials Science
Mass spectrometry
Pharmacology
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Zusammenfassung:A novel derivatization method for the analysis of primary amines by MALDI mass spectrometry is proposed. Tris(2,6-dimethoxyphenyl) methyl carbenium cation reacts smoothly with primary amines, forming permanently charged adducts with the mass increment +359 Da and absorbance in the UV region. The approach was tested on a number of amines, including biologically active compounds and therapeutic agents.
ISSN:1061-9348
1608-3199
DOI:10.1134/S106193481614015X