Chemical transformations of tetracyclo[3.3.1.13,7.01,3]decane (1,3-dehydroadamantane): II. Reaction of 1,3-dehydroadamantane with N,N-dialkylcarboxamides

Chemical transformations of tetracyclo[3.3.1.13,7.01,3]decane (1,3-dehydroadamantane): II. Reaction of 1,3-dehydroadamantane with N,N-dialkylcarboxamides

Alkylation of N,N -dialkylcarboxamides with 1,3-dehydroadamantane has been accomplished for the first time. The reaction involves the C–H bond in the α-position with respect to the carbonyl group and provides a convenient one-step preparation of substituted carboxylic acid amides containing an 1-ada...

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Veröffentlicht in:Russian journal of organic chemistry 2017, Vol.53 (1), p.6-8
Hauptverfasser: Mokhov, V. M., Butov, G. M., Saad, K. R.
Format: Artikel
Sprache:eng
Schlagworte:
Alkylation
Amides
Carbonyl groups
Carbonyls
Carboxylic acids
Chemistry
Chemistry and Materials Science
Hydrogen bonds
Organic Chemistry
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Zusammenfassung:Alkylation of N,N -dialkylcarboxamides with 1,3-dehydroadamantane has been accomplished for the first time. The reaction involves the C–H bond in the α-position with respect to the carbonyl group and provides a convenient one-step preparation of substituted carboxylic acid amides containing an 1-adamantyl substituent and a pharmacophoric group in the amide moiety.
ISSN:1070-4280
1608-3393
DOI:10.1134/S107042801701002X