Synthesis of fluoroquinoxalin-2(1H)-one derivatives containing substituents in the pyrazine and benzene fragments

6,7-Difluoroquinoxalin-2-one reacted with indoles, 5,5-dimethylcyclohexane-1,3-dione, 3-methyl-1-phenyl-1 H -pyrazol-5(4 H )-one, resorcinol, and pyrogallol on heating in acetic acid to give products of hydrogen substitution in the heterocyclic fragment. Heating of 6,7-difluoro-3-(1 H -indol-3-yl)quinoxalin-2(1 H )-ones with N -methylpiperazine gave the corresponding 7-(4-methylpiperazin-1-yl) derivatives.