Sc(OTf)3 catalyzed synthesis of novel 6-phenyl-6H-chromeno[4,3-b]quinolines and evaluation of their cytotoxicity

Novel 6-phenyl-6 H -chromeno[4,3-b]quinoline derivatives have been prepared by reaction of 4-chloro-2-phenyl-2 H -chromene-3-carbaldehyde with various aromatic amines using 5 mol % of Sc(OTf)3 in acetonitile. This is the first example of one-pot synthesis of 6-phenyl-6 H -chromeno[4,3- b ]quinoline from 4-chloro-2-phenyl-2 H -chromene-3-carbaldehyde at ambient temperature. Preliminary evaluation of cytotoxic activity of these chromeno[4,3- b ]quinoline derivatives has been carried out. Some products exhibited anti cancer activity against two carcinoma cell lines A549 and B-16.