159 Neutrophil-to-lymphocyte ratio and systemic lupus erythematosus: a new parameter for disease activity assessment?

Background and aimsSystemic Lupus Erythematosus (SLE) is a complex autoimmune disease characterised by enhanced apoptosis in conjunction with high levels of autoantibodies and deregulated cytokine productions. It contributes to immune dysfunction, tissue inflammation, and organ damage. Neutrophil to Lymphocyte ratio (NLR) is a promising marker in SLE, but its relationships with SLE’s disease activity in Indonesian population has not been evaluated.To investigate the correlation between NLR and SLE disease activity.MethodsA cross sectional study with consecutive sampling technique was conducted with 70 Indonesian SLE patients in Dr. Soetomo Hospital Surabaya at May 2016-July 2016. Peripheral blood count was evaluated during assessment with flowcytometry technique and disease activity was evaluated with Systemic Lupus Activity Measure (SLAM) score. Data analysis was done with Spearman’s correlation rank test and ROC curve using SPSS v22.0.ResultsThere were 19 patients with SLAM score