160 Dyslipidemia and disease activity in systemic lupus erythematous: an independent risk factor

Background and aimsSystemic Lupus Erythematosus (SLE) patients have been associated with increased cardiovascular morbidity and mortality due to atherosclerosis. Dyslipidemia, a traditional atherosclerosis risk factor, has been reported as a long-term independent risk factor in SLE patients. Patients with high disease activity are in heightened inflammatory state, thus altering their lipid profile and accelerate plaque formation.To investigate the correlation lipid profile with disease activity in Indonesian SLE patients.MethodsAn observational cross-sectional study was conducted in May 2016-August 2016 in Dr. Soetomo Hospital Surabaya involving 73 SLE patients. Disease activity was measured with Systemic Lupus Activity Measure (SLAM) score. Lipid profile was assessed at the time of assessment preceded by 10 hours fasting. Patients with previous history of dyslipidemia and receiving lipid-lowering agents were excluded. Data analysis was done with Spearman’s correlation rank test and backward linear regression with SPSS v22.0.ResultsThere were 21 patients with SLAM score