IMPAIRED AUTOPHAGIC FLUX CONTRIBUTES TO THE ACCUMULATION OF UBIQUITINATED PROTEINS IN A MOUSE MODEL OF HEART FAILURE

Interestingly, these ubiquitinated proteins are found in aggregates with p62, which is known to bind to ubiquitin tagged proteins and targets them to autophagosomes. [...]there is increased p62 protein expression consistent with an accumulation of autophagy substrates.

Bibliographische Detailangaben

Veröffentlicht in:	Journal of the American College of Cardiology 2017-03, Vol.69 (11), p.872-872
Hauptverfasser:	Hartupee, Justin, Diwan, Abhinav, Barger, Philip, Mann, Douglas
Format:	Artikel
Sprache:	eng
Schlagworte:	Autophagy Cardiology Cardiovascular Gene expression Heart failure Internal Medicine Proteins
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!