IMPAIRED AUTOPHAGIC FLUX CONTRIBUTES TO THE ACCUMULATION OF UBIQUITINATED PROTEINS IN A MOUSE MODEL OF HEART FAILURE

IMPAIRED AUTOPHAGIC FLUX CONTRIBUTES TO THE ACCUMULATION OF UBIQUITINATED PROTEINS IN A MOUSE MODEL OF HEART FAILURE

Interestingly, these ubiquitinated proteins are found in aggregates with p62, which is known to bind to ubiquitin tagged proteins and targets them to autophagosomes. [...]there is increased p62 protein expression consistent with an accumulation of autophagy substrates.

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Veröffentlicht in:Journal of the American College of Cardiology 2017-03, Vol.69 (11), p.872-872
Hauptverfasser: Hartupee, Justin, Diwan, Abhinav, Barger, Philip, Mann, Douglas
Format: Artikel
Sprache:eng
Schlagworte:
Autophagy
Cardiology
Cardiovascular
Gene expression
Heart failure
Internal Medicine
Proteins
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Zusammenfassung:Interestingly, these ubiquitinated proteins are found in aggregates with p62, which is known to bind to ubiquitin tagged proteins and targets them to autophagosomes. [...]there is increased p62 protein expression consistent with an accumulation of autophagy substrates.
ISSN:0735-1097
1558-3597
DOI:10.1016/S0735-1097(17)34261-4