CELL-SPECIFIC DISCRIMINATION OF DESMOSTEROL AND DESMOSTEROL MIMETICS CONFERS SELECTIVE REGULATION OF LXR AND SREBP PATHWAYS IN MACROPHAGES

CELL-SPECIFIC DISCRIMINATION OF DESMOSTEROL AND DESMOSTEROL MIMETICS CONFERS SELECTIVE REGULATION OF LXR AND SREBP PATHWAYS IN MACROPHAGES

Unbiased whole transcriptome gene expression analysis (RNA-Seq) of mouse and human macrophages and hepatocytes was performed following treatment with desmosterol and novel desmosterol mimetics.

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Bibliographische Detailangaben
Veröffentlicht in:Journal of the American College of Cardiology 2017-03, Vol.69 (11), p.2556-2556
Hauptverfasser: Muse, Evan, Yu, Shan, Edillor, Chantle, Tao, Jenhan, Spann, Nathan, Ozeki, Katherine, McDonald, Jeffrey, Bahadorani, John, Tsimikas, Sotirios, Watt, Andrew, Hettrick, Lisa, Grossman, Tamar, Tremblay, Matthew, Glass, Christopher
Format: Artikel
Sprache:eng
Schlagworte:
Cardiology
Cardiovascular
Discrimination
Gene expression
Internal Medicine
Rodents
Sterols
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Beschreibung
Zusammenfassung:Unbiased whole transcriptome gene expression analysis (RNA-Seq) of mouse and human macrophages and hepatocytes was performed following treatment with desmosterol and novel desmosterol mimetics.
ISSN:0735-1097
1558-3597
DOI:10.1016/S0735-1097(17)35945-4