Comparison of Ivermectin and Diethylcarbamazine in the Treatment of Onchocerciasis

We compared ivermectin with diethylcarbamazine for the treatment of onchocerciasis in a double-blind, placebo-controlled trial. Thirty men with moderate to heavy infection and ocular involvement were randomly assigned to receive ivermectin in a single oral dose (200 μg per kilogram of body weight),...

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Veröffentlicht in:	The New England journal of medicine 1985-07, Vol.313 (3), p.133-138
Hauptverfasser:	Greene, Bruce M, Taylor, Hugh R, Cupp, Eddie W, Murphy, Robert P, White, Albert T, Aziz, Mohammed A, Schulz-Key, Hartwig, D'Anna, Salvatore A, Newland, Henry S, Goldschmidt, Leonard P, Auer, Cheryl, Hanson, Aloysius P, Freeman, S. Vaanii, Reber, Earl W, Williams, P. Noel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anthelmintics - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic Agents Biological and medical sciences Biomedical research Body weight Clinical Trials as Topic Cornea Cornea - parasitology Corneal Opacity - chemically induced Diethylcarbamazine - adverse effects Diethylcarbamazine - therapeutic use Dirofilaria immitis Double-Blind Method Eye Diseases - drug therapy Eye Diseases - etiology Filaricides - adverse effects Filaricides - therapeutic use Hospitals Humans Infections Ivermectin Laboratories Lactones - adverse effects Lactones - therapeutic use Male Medical imaging Medical sciences Medicine Middle Aged Nodules Onchocerca volvulus Onchocerciasis Onchocerciasis - complications Onchocerciasis - drug therapy Onchocerciasis - parasitology Pharmacology. Drug treatments Pruritus Random Allocation Skin Skin - parasitology Skin Diseases, Parasitic - parasitology Time Factors
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Beschreibung
Zusammenfassung:	We compared ivermectin with diethylcarbamazine for the treatment of onchocerciasis in a double-blind, placebo-controlled trial. Thirty men with moderate to heavy infection and ocular involvement were randomly assigned to receive ivermectin in a single oral dose (200 μg per kilogram of body weight), diethylcarbamazine daily for eight days, or placebo. Diethylcarbamazine caused a significantly more severe systemic reaction than ivermectin (P
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJM198507183130301