Serum Sickness and Immune Complexes

The article by Lawley et al. 1 in this issue of the Journal provides an excellent description of the clinical and immunologic features of serum sickness in patients with bone-marrow failure who received antithymocyte globulin in horse serum. This group of patients, similar to those described by von...

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Veröffentlicht in:The New England journal of medicine 1984-11, Vol.311 (22), p.1435-1436
1. Verfasser: Gilliland, Bruce C
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creator Gilliland, Bruce C
description The article by Lawley et al. 1 in this issue of the Journal provides an excellent description of the clinical and immunologic features of serum sickness in patients with bone-marrow failure who received antithymocyte globulin in horse serum. This group of patients, similar to those described by von Pirquet and Schick in 1905, 2 acquired fever, skin lesions, arthralgias, lymphadenopathy, gastrointestinal symptoms, and mild proteinuria 8 to 13 days after beginning therapy. The relation of the formation of immune complexes to the development of clinical manifestations in these patients is well documented. A rise in the level of immune complexes was accompanied . . .
doi_str_mv 10.1056/NEJM198411293112210
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ispartof The New England journal of medicine, 1984-11, Vol.311 (22), p.1435-1436
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subjects Antigen-Antibody Complex - analysis
Antigen-Antibody Complex - immunology
Antigen-antibody complexes
Humans
Serum sickness
Serum Sickness - immunology
title Serum Sickness and Immune Complexes
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