Parallel synthesis and automated data analysis: a versatile decision tool

Parallel synthesis and automated data analysis: a versatile decision tool

The problems associated with the use of combinatorial chemistry in lead generation and optimization are discussed. A post‐synthesis data evaluation process is described which can cope with large data sets from parallel synthesis effects. It relies on analysis of purity as well as on identification,...

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Veröffentlicht in:Pesticide Science 1999-03, Vol.55 (3), p.374-376
Hauptverfasser: Diggelmann, Martin, Gassmann, Ernst, Stämpfli, Andreas
Format: Artikel
Sprache:eng
Schlagworte:
combinatorial chemistry
decision algorithm
parallel synthesis
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Zusammenfassung:The problems associated with the use of combinatorial chemistry in lead generation and optimization are discussed. A post‐synthesis data evaluation process is described which can cope with large data sets from parallel synthesis effects. It relies on analysis of purity as well as on identification, and can efficiently limit compounds screened to manageable numbers. © 1999 Society of Chemical Industry
ISSN:0031-613X
1526-498X
1096-9063
DOI:10.1002/(SICI)1096-9063(199903)55:3<374::AID-PS914>3.0.CO;2-5