Treatment of Lactic Acidosis with Dichloroacetate

We administered dichloroacetate, which prevents or reverses hyperlactatemia in animals and lowers plasma lactate levels in human beings, to 13 patients with lactic acidosis of various causes. All had hypotension, and their acidemia had resisted treatment with sodium bicarbonate. The metabolic effect...

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Veröffentlicht in:	The New England journal of medicine 1983-08, Vol.309 (7), p.390-396
Hauptverfasser:	Stacpoole, Peter W, Harman, Eloise M, Curry, Stephen H, Baumgartner, Thomas G, Misbin, Robert I
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Hydroxybutyric Acid Acetates - therapeutic use Acidosis Acidosis - drug therapy Adolescent Adult Aged Alanine - blood Bicarbonates Bicarbonates - blood Blood pressure Blood Pressure - drug effects Dehydrogenases Diabetes Dichloroacetic acid Dichloroacetic Acid - administration & dosage Dichloroacetic Acid - blood Dichloroacetic Acid - therapeutic use Drug dosages Endocrinology Enzymes Female Heart diseases Humans Hydrogen-Ion Concentration Hydroxybutyrates - blood Hyperlactatemia Hypotension Insulin Lactates - blood Lactic Acid Lactic acidosis Male Metabolism Middle Aged Patients pH effects Pharmacy Plasma Sepsis Sodium Sodium bicarbonate Toxicity
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Zusammenfassung:	We administered dichloroacetate, which prevents or reverses hyperlactatemia in animals and lowers plasma lactate levels in human beings, to 13 patients with lactic acidosis of various causes. All had hypotension, and their acidemia had resisted treatment with sodium bicarbonate. The metabolic effects of dichloroacetate were evaluated in 11 patients. In seven dichloroacetate significantly reduced the level of arterial blood lactate (P
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJM198308183090702