PX-478 prevents gut inflammation and normalizes the expression of tight junction proteins following ethanol and burn injury

PX-478 prevents gut inflammation and normalizes the expression of tight junction proteins following ethanol and burn injury

Additionally, hypoxia inducible factor (HIF)-1α, a marker of hypoxia was significantly elevated in small intestinal epithelial cells (IECs) following the combined insult. Since hypoxia can result in increased inflammation and tissue damage, we treated a group of mice with HIF-1α inhibitor PX-478 t...

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Veröffentlicht in:Alcohol (Fayetteville, N.Y.) N.Y.), 2017-03, Vol.59, p.73-74
Hauptverfasser: Morris, N.L, Hammer, A.M, Cannon, A.R, Gagnon, R, Li, X, Choudhry, M.A
Format: Artikel
Sprache:eng
Schlagworte:
Burns
Hypoxia
Inflammation
Protein expression
Psychiatry
Small intestine
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Zusammenfassung:Additionally, hypoxia inducible factor (HIF)-1α, a marker of hypoxia was significantly elevated in small intestinal epithelial cells (IECs) following the combined insult. Since hypoxia can result in increased inflammation and tissue damage, we treated a group of mice with HIF-1α inhibitor PX-478 to determine whether hypoxia modulates tight junction protein expression and inflammation in the intestine following ethanol and burn injury.
ISSN:0741-8329
1873-6823
DOI:10.1016/j.alcohol.2016.10.026