Mechanistic role of Per2 and PPAR-gamma in ethanol mediated hyperpermeability

Mechanistic role of Per2 and PPAR-gamma in ethanol mediated hyperpermeability

To elucidate the role of PPAR-gamma protein in ethanol-induced epithelial barrier dysfunction, we grew Caco-2 cells on cell culture microplates until confluence. TEER reconfirmed the negative effect of ethanol on epithelial barrier function.

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Bibliographische Detailangaben
Veröffentlicht in:Alcohol (Fayetteville, N.Y.) N.Y.), 2017-03, Vol.59, p.72-73
Hauptverfasser: Davis, B.T, Shaikh, M, Forsyth, C.B, Keshavarzian, A
Format: Artikel
Sprache:eng
Schlagworte:
Ethanol
Oxidative stress
Permeability
Proteins
Psychiatry
Small intestine
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Beschreibung
Zusammenfassung:To elucidate the role of PPAR-gamma protein in ethanol-induced epithelial barrier dysfunction, we grew Caco-2 cells on cell culture microplates until confluence. TEER reconfirmed the negative effect of ethanol on epithelial barrier function.
ISSN:0741-8329
1873-6823
DOI:10.1016/j.alcohol.2016.10.023