Fertility and Outcome of Pregnancy in Women Exposed in Utero to Diethylstilbestrol
Fertility and outcome of pregnancy were examined in women participating in the National Cooperative Diethylstilbestrol Adenosis (DESAD) Project. We compared 618 subjects who had prenatal exposure to DES with 618 control subjects. Fertility, measured in terms of pregnancies achieved, did not differ b...
Gespeichert in:
| Veröffentlicht in: | The New England journal of medicine 1980-03, Vol.302 (11), p.609-613 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 613 |
|---|---|
| container_issue | 11 |
| container_start_page | 609 |
| container_title | The New England journal of medicine |
| container_volume | 302 |
| creator | Barnes, Ann B Colton, Theodore Gundersen, Jerome Noller, Kenneth L Tilley, Barbara C Strama, Thomas Townsend, Duane E Hatab, Paul O'Brien, Peter C |
| description | Fertility and outcome of pregnancy were examined in women participating in the National Cooperative Diethylstilbestrol Adenosis (DESAD) Project. We compared 618 subjects who had prenatal exposure to DES with 618 control subjects. Fertility, measured in terms of pregnancies achieved, did not differ between the women exposed to DES and the controls. An increased risk of unfavorable outcome of pregnancy was associated with DES exposure (the relative risk of any unfavorable outcome of pregnancy was 1.69; P |
| doi_str_mv | 10.1056/NEJM198003133021105 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1868762339</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4314626761</sourcerecordid><originalsourceid>FETCH-LOGICAL-c402t-9ee52ccb37cfe0125b829f80dbc7c394330e05a7f2ebfad72212cced45aa664d2</originalsourceid><addsrcrecordid>eNp9UNtKw0AUXESptfoFIiz4KNG95bKPoq0XqhWx-Bg2mxNNSbJ1dwPm793S4pN4Xg7MzJnhDEKnlFxSEidXz9PHJyozQjjlnDAawD00pjHnkRAk2UdjQlgWiVTyQ3Tk3IqEoUKO0CjlMZUkG6PXGVhfN7UfsOpKvOi9Ni1gU-EXCx-d6vSA6w6_B7DD0--1cVBugKUHa7A3-LYG_zk0LpgU4Lw1zTE6qFTj4GS3J2g5m77d3Efzxd3DzfU80oIwH0mAmGld8FRXQCiLi4zJKiNloVPNpQgvAYlVWjEoKlWmjNEgh1LESiWJKNkEnW9919Z89SE7X5nediEyp1mSpQnjXAYV36q0Nc5ZqPK1rVtlh5ySfFNj_keN4eps590XLZS_N7veAn-x5dvW5R2s2n_dfgD8OXmZ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1868762339</pqid></control><display><type>article</type><title>Fertility and Outcome of Pregnancy in Women Exposed in Utero to Diethylstilbestrol</title><source>MEDLINE</source><creator>Barnes, Ann B ; Colton, Theodore ; Gundersen, Jerome ; Noller, Kenneth L ; Tilley, Barbara C ; Strama, Thomas ; Townsend, Duane E ; Hatab, Paul ; O'Brien, Peter C</creator><creatorcontrib>Barnes, Ann B ; Colton, Theodore ; Gundersen, Jerome ; Noller, Kenneth L ; Tilley, Barbara C ; Strama, Thomas ; Townsend, Duane E ; Hatab, Paul ; O'Brien, Peter C</creatorcontrib><description>Fertility and outcome of pregnancy were examined in women participating in the National Cooperative Diethylstilbestrol Adenosis (DESAD) Project. We compared 618 subjects who had prenatal exposure to DES with 618 control subjects. Fertility, measured in terms of pregnancies achieved, did not differ between the women exposed to DES and the controls. An increased risk of unfavorable outcome of pregnancy was associated with DES exposure (the relative risk of any unfavorable outcome of pregnancy was 1.69; P<0.001). Speculation on biologic mechanisms that might produce this difference is premature, since additional data about these subjects must be collected. Among DES-exposed women who became pregnant, 81 per cent had at least one full-term live birth. (N Engl J Med. 1980; 302:609–13.)
This report concerns preliminary findings on fertility and outcome of pregnancy in a subgroup of women enrolled in the National Cooperative Diethylstilbestrol Adenosis (DESAD) Project. In a study comparing 229 women who had been exposed to diethylstilbestrol (DES) in utero with 136 controls, Bibbo et al. found a history of pregnancy in only 18 per cent of the women exposed to DES, as compared with 33 per cent of the controls.
1
The rate of pregnancy resulting in live births was significantly higher among controls (23 per cent) than among women exposed to DES (13 per cent); miscarriages occurred in 11 . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM198003133021105</identifier><identifier>PMID: 7351908</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Abnormalities, Drug-Induced - etiology ; Abortion ; Abortion, Spontaneous - epidemiology ; Adolescent ; Adult ; Age ; Analysis of Variance ; Cancer ; Cervix Uteri - abnormalities ; Confidence intervals ; Daughters ; Diethylstilbestrol ; Diethylstilbestrol - adverse effects ; Drug dosages ; Family medical history ; Female ; Fertility ; Fetus - drug effects ; Hospitals ; Humans ; Infertility, Female - epidemiology ; Maternal-Fetal Exchange ; Miscarriage ; Mothers ; Pregnancy ; Pregnancy complications ; Prenatal experience ; Prenatal exposure ; Stillbirth ; United States ; Vagina - abnormalities ; Womens health</subject><ispartof>The New England journal of medicine, 1980-03, Vol.302 (11), p.609-613</ispartof><rights>Copyright Massachusetts Medical Society Mar 13, 1980</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-9ee52ccb37cfe0125b829f80dbc7c394330e05a7f2ebfad72212cced45aa664d2</citedby><cites>FETCH-LOGICAL-c402t-9ee52ccb37cfe0125b829f80dbc7c394330e05a7f2ebfad72212cced45aa664d2</cites></display><links><openurl>$$Topenurl_article</openurl><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>776</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7351908$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barnes, Ann B</creatorcontrib><creatorcontrib>Colton, Theodore</creatorcontrib><creatorcontrib>Gundersen, Jerome</creatorcontrib><creatorcontrib>Noller, Kenneth L</creatorcontrib><creatorcontrib>Tilley, Barbara C</creatorcontrib><creatorcontrib>Strama, Thomas</creatorcontrib><creatorcontrib>Townsend, Duane E</creatorcontrib><creatorcontrib>Hatab, Paul</creatorcontrib><creatorcontrib>O'Brien, Peter C</creatorcontrib><title>Fertility and Outcome of Pregnancy in Women Exposed in Utero to Diethylstilbestrol</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Fertility and outcome of pregnancy were examined in women participating in the National Cooperative Diethylstilbestrol Adenosis (DESAD) Project. We compared 618 subjects who had prenatal exposure to DES with 618 control subjects. Fertility, measured in terms of pregnancies achieved, did not differ between the women exposed to DES and the controls. An increased risk of unfavorable outcome of pregnancy was associated with DES exposure (the relative risk of any unfavorable outcome of pregnancy was 1.69; P<0.001). Speculation on biologic mechanisms that might produce this difference is premature, since additional data about these subjects must be collected. Among DES-exposed women who became pregnant, 81 per cent had at least one full-term live birth. (N Engl J Med. 1980; 302:609–13.)
This report concerns preliminary findings on fertility and outcome of pregnancy in a subgroup of women enrolled in the National Cooperative Diethylstilbestrol Adenosis (DESAD) Project. In a study comparing 229 women who had been exposed to diethylstilbestrol (DES) in utero with 136 controls, Bibbo et al. found a history of pregnancy in only 18 per cent of the women exposed to DES, as compared with 33 per cent of the controls.
1
The rate of pregnancy resulting in live births was significantly higher among controls (23 per cent) than among women exposed to DES (13 per cent); miscarriages occurred in 11 . . .</description><subject>Abnormalities, Drug-Induced - etiology</subject><subject>Abortion</subject><subject>Abortion, Spontaneous - epidemiology</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Analysis of Variance</subject><subject>Cancer</subject><subject>Cervix Uteri - abnormalities</subject><subject>Confidence intervals</subject><subject>Daughters</subject><subject>Diethylstilbestrol</subject><subject>Diethylstilbestrol - adverse effects</subject><subject>Drug dosages</subject><subject>Family medical history</subject><subject>Female</subject><subject>Fertility</subject><subject>Fetus - drug effects</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infertility, Female - epidemiology</subject><subject>Maternal-Fetal Exchange</subject><subject>Miscarriage</subject><subject>Mothers</subject><subject>Pregnancy</subject><subject>Pregnancy complications</subject><subject>Prenatal experience</subject><subject>Prenatal exposure</subject><subject>Stillbirth</subject><subject>United States</subject><subject>Vagina - abnormalities</subject><subject>Womens health</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>false</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9UNtKw0AUXESptfoFIiz4KNG95bKPoq0XqhWx-Bg2mxNNSbJ1dwPm793S4pN4Xg7MzJnhDEKnlFxSEidXz9PHJyozQjjlnDAawD00pjHnkRAk2UdjQlgWiVTyQ3Tk3IqEoUKO0CjlMZUkG6PXGVhfN7UfsOpKvOi9Ni1gU-EXCx-d6vSA6w6_B7DD0--1cVBugKUHa7A3-LYG_zk0LpgU4Lw1zTE6qFTj4GS3J2g5m77d3Efzxd3DzfU80oIwH0mAmGld8FRXQCiLi4zJKiNloVPNpQgvAYlVWjEoKlWmjNEgh1LESiWJKNkEnW9919Z89SE7X5nediEyp1mSpQnjXAYV36q0Nc5ZqPK1rVtlh5ySfFNj_keN4eps590XLZS_N7veAn-x5dvW5R2s2n_dfgD8OXmZ</recordid><startdate>19800313</startdate><enddate>19800313</enddate><creator>Barnes, Ann B</creator><creator>Colton, Theodore</creator><creator>Gundersen, Jerome</creator><creator>Noller, Kenneth L</creator><creator>Tilley, Barbara C</creator><creator>Strama, Thomas</creator><creator>Townsend, Duane E</creator><creator>Hatab, Paul</creator><creator>O'Brien, Peter C</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>19800313</creationdate><title>Fertility and Outcome of Pregnancy in Women Exposed in Utero to Diethylstilbestrol</title><author>Barnes, Ann B ; Colton, Theodore ; Gundersen, Jerome ; Noller, Kenneth L ; Tilley, Barbara C ; Strama, Thomas ; Townsend, Duane E ; Hatab, Paul ; O'Brien, Peter C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-9ee52ccb37cfe0125b829f80dbc7c394330e05a7f2ebfad72212cced45aa664d2</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Abnormalities, Drug-Induced - etiology</topic><topic>Abortion</topic><topic>Abortion, Spontaneous - epidemiology</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Age</topic><topic>Analysis of Variance</topic><topic>Cancer</topic><topic>Cervix Uteri - abnormalities</topic><topic>Confidence intervals</topic><topic>Daughters</topic><topic>Diethylstilbestrol</topic><topic>Diethylstilbestrol - adverse effects</topic><topic>Drug dosages</topic><topic>Family medical history</topic><topic>Female</topic><topic>Fertility</topic><topic>Fetus - drug effects</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Infertility, Female - epidemiology</topic><topic>Maternal-Fetal Exchange</topic><topic>Miscarriage</topic><topic>Mothers</topic><topic>Pregnancy</topic><topic>Pregnancy complications</topic><topic>Prenatal experience</topic><topic>Prenatal exposure</topic><topic>Stillbirth</topic><topic>United States</topic><topic>Vagina - abnormalities</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><creatorcontrib>Barnes, Ann B</creatorcontrib><creatorcontrib>Colton, Theodore</creatorcontrib><creatorcontrib>Gundersen, Jerome</creatorcontrib><creatorcontrib>Noller, Kenneth L</creatorcontrib><creatorcontrib>Tilley, Barbara C</creatorcontrib><creatorcontrib>Strama, Thomas</creatorcontrib><creatorcontrib>Townsend, Duane E</creatorcontrib><creatorcontrib>Hatab, Paul</creatorcontrib><creatorcontrib>O'Brien, Peter C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>no_fulltext</fulltext></delivery><addata><au>Barnes, Ann B</au><au>Colton, Theodore</au><au>Gundersen, Jerome</au><au>Noller, Kenneth L</au><au>Tilley, Barbara C</au><au>Strama, Thomas</au><au>Townsend, Duane E</au><au>Hatab, Paul</au><au>O'Brien, Peter C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fertility and Outcome of Pregnancy in Women Exposed in Utero to Diethylstilbestrol</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>1980-03-13</date><risdate>1980</risdate><volume>302</volume><issue>11</issue><spage>609</spage><epage>613</epage><pages>609-613</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><abstract>Fertility and outcome of pregnancy were examined in women participating in the National Cooperative Diethylstilbestrol Adenosis (DESAD) Project. We compared 618 subjects who had prenatal exposure to DES with 618 control subjects. Fertility, measured in terms of pregnancies achieved, did not differ between the women exposed to DES and the controls. An increased risk of unfavorable outcome of pregnancy was associated with DES exposure (the relative risk of any unfavorable outcome of pregnancy was 1.69; P<0.001). Speculation on biologic mechanisms that might produce this difference is premature, since additional data about these subjects must be collected. Among DES-exposed women who became pregnant, 81 per cent had at least one full-term live birth. (N Engl J Med. 1980; 302:609–13.)
This report concerns preliminary findings on fertility and outcome of pregnancy in a subgroup of women enrolled in the National Cooperative Diethylstilbestrol Adenosis (DESAD) Project. In a study comparing 229 women who had been exposed to diethylstilbestrol (DES) in utero with 136 controls, Bibbo et al. found a history of pregnancy in only 18 per cent of the women exposed to DES, as compared with 33 per cent of the controls.
1
The rate of pregnancy resulting in live births was significantly higher among controls (23 per cent) than among women exposed to DES (13 per cent); miscarriages occurred in 11 . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>7351908</pmid><doi>10.1056/NEJM198003133021105</doi><tpages>5</tpages></addata></record> |
| fulltext | no_fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 1980-03, Vol.302 (11), p.609-613 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_proquest_journals_1868762339 |
| source | MEDLINE |
| subjects | Abnormalities, Drug-Induced - etiology Abortion Abortion, Spontaneous - epidemiology Adolescent Adult Age Analysis of Variance Cancer Cervix Uteri - abnormalities Confidence intervals Daughters Diethylstilbestrol Diethylstilbestrol - adverse effects Drug dosages Family medical history Female Fertility Fetus - drug effects Hospitals Humans Infertility, Female - epidemiology Maternal-Fetal Exchange Miscarriage Mothers Pregnancy Pregnancy complications Prenatal experience Prenatal exposure Stillbirth United States Vagina - abnormalities Womens health |
| title | Fertility and Outcome of Pregnancy in Women Exposed in Utero to Diethylstilbestrol |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T10%3A05%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Fertility%20and%20Outcome%20of%20Pregnancy%20in%20Women%20Exposed%20in%20Utero%20to%20Diethylstilbestrol&rft.jtitle=The%20New%20England%20journal%20of%20medicine&rft.au=Barnes,%20Ann%20B&rft.date=1980-03-13&rft.volume=302&rft.issue=11&rft.spage=609&rft.epage=613&rft.pages=609-613&rft.issn=0028-4793&rft.eissn=1533-4406&rft_id=info:doi/10.1056/NEJM198003133021105&rft_dat=%3Cproquest_cross%3E4314626761%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1868762339&rft_id=info:pmid/7351908&rfr_iscdi=true |