Fertility and Outcome of Pregnancy in Women Exposed in Utero to Diethylstilbestrol

Fertility and outcome of pregnancy were examined in women participating in the National Cooperative Diethylstilbestrol Adenosis (DESAD) Project. We compared 618 subjects who had prenatal exposure to DES with 618 control subjects. Fertility, measured in terms of pregnancies achieved, did not differ b...

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Veröffentlicht in:	The New England journal of medicine 1980-03, Vol.302 (11), p.609-613
Hauptverfasser:	Barnes, Ann B, Colton, Theodore, Gundersen, Jerome, Noller, Kenneth L, Tilley, Barbara C, Strama, Thomas, Townsend, Duane E, Hatab, Paul, O'Brien, Peter C
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities, Drug-Induced - etiology Abortion Abortion, Spontaneous - epidemiology Adolescent Adult Age Analysis of Variance Cancer Cervix Uteri - abnormalities Confidence intervals Daughters Diethylstilbestrol Diethylstilbestrol - adverse effects Drug dosages Family medical history Female Fertility Fetus - drug effects Hospitals Humans Infertility, Female - epidemiology Maternal-Fetal Exchange Miscarriage Mothers Pregnancy Pregnancy complications Prenatal experience Prenatal exposure Stillbirth United States Vagina - abnormalities Womens health
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Zusammenfassung:	Fertility and outcome of pregnancy were examined in women participating in the National Cooperative Diethylstilbestrol Adenosis (DESAD) Project. We compared 618 subjects who had prenatal exposure to DES with 618 control subjects. Fertility, measured in terms of pregnancies achieved, did not differ between the women exposed to DES and the controls. An increased risk of unfavorable outcome of pregnancy was associated with DES exposure (the relative risk of any unfavorable outcome of pregnancy was 1.69; P
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJM198003133021105