Vascular Endothelium–Specific IL-4Ra Signaling Axis Regulates Severity of IgE-Mediated Anaphylactic Reactions

Vascular Endothelium–Specific IL-4Ra Signaling Axis Regulates Severity of IgE-Mediated Anaphylactic Reactions

[...]using a passive model of food-induced anaphylaxis, IL-4 amplified hypothermia following oral challenge with ovalbumin-TNP in iIL-9Tg VEIL-4Rα WT mice sensitized with anti-TNP IgE (-3.1 ± 0.9 ºC vs. -

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Veröffentlicht in:Journal of allergy and clinical immunology 2017-02, Vol.139 (2), p.AB188-AB188
Hauptverfasser: Yamani, Amnah N., MS, Wu, David, PhD, Waggoner, Lisa, MS, Finkelman, Fred D., MD, Hogan, Simon P., PhD
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Endothelium
Histamine
Rodents
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Zusammenfassung:[...]using a passive model of food-induced anaphylaxis, IL-4 amplified hypothermia following oral challenge with ovalbumin-TNP in iIL-9Tg VEIL-4Rα WT mice sensitized with anti-TNP IgE (-3.1 ± 0.9 ºC vs. -
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2016.12.614