TPSAB1 Genotype and Effects of Pro-Tryptases on Human Mast Cell-Associated Disorders

TPSAB1 Genotype and Effects of Pro-Tryptases on Human Mast Cell-Associated Disorders

Rationale Elevated basal serum tryptase due to increased α-tryptase copy number at TPSAB1 is associated with modest increases in bone marrow mast cell burden and symptoms suggestive of mast cell mediator activity.

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Veröffentlicht in:Journal of allergy and clinical immunology 2017-02, Vol.139 (2), p.AB376-AB376
Hauptverfasser: Lyons, Jonathan, Dr, Chovanec, Jack, Mr, Liu, Yihui, Dr, Quang T. Le, Dr, Bai, Yun, Ms, Hsu, Amy P., Ms, Komarow, Hirsh D., Dr, Carter, Melody C., Dr, Schwartz, Lawrence B., Dr, Metcalfe, Dean D., Dr, Milner, Joshua D., Dr
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Bone marrow
Genes
Genotype & phenotype
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Zusammenfassung:Rationale Elevated basal serum tryptase due to increased α-tryptase copy number at TPSAB1 is associated with modest increases in bone marrow mast cell burden and symptoms suggestive of mast cell mediator activity.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2016.12.900