Crucial Role of Langerhans Cells in Allergen Uptake and Regulatory T Cell Induction in Epicutaneous Immunotherapy

Crucial Role of Langerhans Cells in Allergen Uptake and Regulatory T Cell Induction in Epicutaneous Immunotherapy

Conclusions Although both LCs and CD11b+ DCs could uptake allergen and induce Tregs, absence of LCs impaired the induction of Tregs in vivo indicating their crucial role in skin-induced tolerance during EPIT.

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Veröffentlicht in:Journal of allergy and clinical immunology 2017-02, Vol.139 (2), p.AB257-AB257
Hauptverfasser: Dioszeghy, Vincent, PhD, Mondoulet, Lucie, Dhelft, Veronique, Ligouis, Melanie, Plaquet, Camille, Dupont, Christophe M., MD, PhD, Sampson, Hugh A., MD, FAAAAI, Benhamou, Pierre-Henri
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Immunotherapy
Rodents
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Zusammenfassung:Conclusions Although both LCs and CD11b+ DCs could uptake allergen and induce Tregs, absence of LCs impaired the induction of Tregs in vivo indicating their crucial role in skin-induced tolerance during EPIT.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2016.12.826