A Paradox: [alpha]-Klotho Levels and Smoking Intensity

Reports regarding smoking differences in [alpha]-klotho expression have provided conflicting results. In the current study we focused on the influence of smoking intensity to serum levels of the aging molecule [alpha]-klotho in healthy smokers. 40 middle aged healthy smokers without airway obstruction or restriction were selected for the analysis. Serum levels of soluble [alpha]-klotho were significantly higher in heavy smokers (P < 0.001). These results are in agreement with the possibility that [alpha]-klotho acts as anti-inflammatory molecule and strengthen the hypothesis that an increase of serum levels of [alpha]-klotho might be a compensatory response to smoking stress in healthy population.