Role of [alpha]7-nicotinic acetylcholine receptors of B cells in the immunotoxic effect of organophosphorus compounds

Role of [alpha]7-nicotinic acetylcholine receptors of B cells in the immunotoxic effect of organophosphorus compounds

Experiments on white non-inbred rats demonstrated that treatment with organophosphorus compound dimethyl dichlorovinyl phosphate (DDVP) decreased T cell-independent antibody production by B cells and blood levels of IL-10 and IL-12; a similar effect was produced by GTS-21, a selective agonist of [al...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Bulletin of experimental biology and medicine 2016-10, Vol.161 (6), p.779
Hauptverfasser: Zabrodskii, P.F, Maslyakov, V.V, Gromov, M.S
Format: Artikel
Sprache:eng
Schlagworte:
Animal experimentation
Antibodies
B cells
Organic phosphorus compounds
Poisoning
T cells
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Experiments on white non-inbred rats demonstrated that treatment with organophosphorus compound dimethyl dichlorovinyl phosphate (DDVP) decreased T cell-independent antibody production by B cells and blood levels of IL-10 and IL-12; a similar effect was produced by GTS-21, a selective agonist of [alpha]7-nicotinic acetylcholine receptor. N-nicotinic receptor antagonist chlorisondamine in combination with DDVP partially prevented suppression of antibody production in comparison with the effect observed during intoxication with DDVP. Key Words: organophosphorus compounds; B cells; [alpha]7-nicotinic acetylcholine receptors; IL-10; IL-12
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-016-3508-x