Catenin Expression Negatively Correlates with WIF1 and Predicts Poor Clinical Outcomes in Patients with Cervical Cancer

Catenin Expression Negatively Correlates with WIF1 and Predicts Poor Clinical Outcomes in Patients with Cervical Cancer

Aberrant activation of the canonical Wnt pathway plays a significant role in cervical cancer (CC). However, limited data show the correlation between the cancer clinicopathological characteristics and the key molecules such as β-catenin and Wnt inhibitory factor 1 (WIF1). In this study, β-catenin an...

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Veröffentlicht in:BioMed research international 2016-01, Vol.2016
Hauptverfasser: Liang, Jinxiao, Zhou, Hui, Peng, Yongpai, Xie, Xiaofei, Li, Ruixin, Liu, Yunyun, Xie, Qingsheng, Lin, Zhongqiu
Format: Artikel
Sprache:eng
Schlagworte:
Cancer patients
Cancer therapies
Cell cycle
Cell division
Cervical cancer
Clinical outcomes
Cytoplasm
Development and progression
Immunohistochemistry
Ligands
Lymphatic system
Medical prognosis
Medical research
Medicine, Experimental
Metastasis
Multivariate analysis
Patient outcomes
Statistical analysis
Studies
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Zusammenfassung:Aberrant activation of the canonical Wnt pathway plays a significant role in cervical cancer (CC). However, limited data show the correlation between the cancer clinicopathological characteristics and the key molecules such as β-catenin and Wnt inhibitory factor 1 (WIF1). In this study, β-catenin and WIF1 expression were analyzed by immunohistochemistry for 196 patients with CC, 39 with cervical intraepithelial neoplasia (CIN), and 41 with normal cervical epithelium (NCE). Significant overexpression of β-catenin was detected in CC (67.9%) when compared to CIN (43.6%) or NCE (34.1%), p
ISSN:2314-6133
2314-6141
DOI:10.1155/2016/4923903