DBU Acetate Mediated: One-pot Multi Component Syntheses of Dihydropyrano[3,2-c]quinolones

Three‐component reaction involving condensation of 1‐methylquinoline‐2,4(1H,3H)‐dione(1), aromatic aldehydes (2a, 2b, 2c, 2d, 2e, 2f, 2g, 2h) and malononitrile/cyanoaceticester (3a, 3b) in{(1,8‐diazabicyclo[5.4.0]‐undec‐7‐en‐8‐ium acetate)}[DBU][Ac] as task‐specific ionic liquid leading to the effic...

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Veröffentlicht in:Journal of heterocyclic chemistry 2016-11, Vol.53 (6), p.1911-1916
Hauptverfasser: Bhupathi, Rajasekar, Madhu, Bandi, Devi, B. Rama, Reddy, Ch. Venkata Ramana, Dubey, P. K.
Format: Artikel
Sprache:eng
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Zusammenfassung:Three‐component reaction involving condensation of 1‐methylquinoline‐2,4(1H,3H)‐dione(1), aromatic aldehydes (2a, 2b, 2c, 2d, 2e, 2f, 2g, 2h) and malononitrile/cyanoaceticester (3a, 3b) in{(1,8‐diazabicyclo[5.4.0]‐undec‐7‐en‐8‐ium acetate)}[DBU][Ac] as task‐specific ionic liquid leading to the efficient synthesis of dihydropyrano[3,2‐c]quinolones (4a, 4b, 4c, 4d, 4e, 4f, 4g, 4h, 4i, 4j, 4k, 4l, 4m, 4n, 4o, 4p) is described. This approach is convenient, mild, and affords the products in high yields without the use of column chromatography.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.2506