Catalytic Thiourea Promoted Electrophilic Thiocyanation of Indoles and Aromatic Amines with NCS/NH4SCN

A simple and efficient protocol for the electrophilic thiocyanation of indoles and aromatic amines with thiourea/NCS/NH4SCN system has been developed. The major features of the present procedure are the mild conditions, good yields, short reaction times, and the use of inexpensive and readily availa...

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Veröffentlicht in:	Chinese journal of chemistry 2016-11, Vol.34 (11), p.1081-1085
Hauptverfasser:	Wang, Cancan, Wang, Zhonghao, Wang, Liang, Chen, Qun, He, Mingyang
Format:	Artikel
Sprache:	eng
Schlagworte:	aromatic amines catalytic thiourea indoles N-chlorosuccinimide NCS thiocyanation 反应时间吲哚电催化硫氰酸硫脲芳香胺苯环
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Beschreibung
Zusammenfassung:	A simple and efficient protocol for the electrophilic thiocyanation of indoles and aromatic amines with thiourea/NCS/NH4SCN system has been developed. The major features of the present procedure are the mild conditions, good yields, short reaction times, and the use of inexpensive and readily available organocatalyst. Moreover, N-chlorosueeinimide （NCS） was found to be indispensable, and thiourea could greatly promote the reaction.
ISSN:	1001-604X 1614-7065
DOI:	10.1002/cjoc.201600344