Effects of Aging on Bone Formation Induced by BMP-2 using Low-intensity Pulsed Ultrasound

The purpose of this study was to evaluate the effects of aging on bone formation induced by Bone Morphogenetic Protein-2 (BMP-2) using low-intensity pulsed ultrasound (LIPUS)in 12-week-old (12w group) and 70-week-old (70w group) Wistar rats.The experimental sites (palatal subperiosteal sites) were d...

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Veröffentlicht in:	Journal of Oral Tissue Engineering 2016, Vol.14(1), pp.65-69
Hauptverfasser:	YAMAJI, Kozo, YOKOYAMA, Akihito, MATSUZAKI, Kumiko, OHARA, Naoko, NISHIYAMA, Eriko, SUGAYA, Tsutomu, YOSHIYAMA, Masahiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging BMP bone formation Bone growth Bone morphogenetic protein 2 Bone surgery Implantation LIPUS Osteogenesis Rats Rodents Ultrasonic imaging Ultrasound
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Zusammenfassung:	The purpose of this study was to evaluate the effects of aging on bone formation induced by Bone Morphogenetic Protein-2 (BMP-2) using low-intensity pulsed ultrasound (LIPUS)in 12-week-old (12w group) and 70-week-old (70w group) Wistar rats.The experimental sites (palatal subperiosteal sites) were divided into three sites as follows: BMP site, BMP-2 was implanted; LI-BMP site, LIPUS treatment was performed every three days after implantation of BMP-2; and Control site, neither implantation of BMP-2 nor LIPUS treatment was done.At 3 weeks after surgery, thickness of new bone (TNB) was significantly higher in both the BMP and LI-BMP sites than in the Control site (P
ISSN:	1348-9623 1880-0823
DOI:	10.11223/jarde.14.65