TCT-196 From Door to Balloon to Door to Unload: A Transcriptomic Analysis Identifies that Primary Unloading Globally Shifts Gene Expression and Preserves Mitochondrial Integrity within the Infarct Zone during the Acute Phase of AMI

TCT-196 From Door to Balloon to Door to Unload: A Transcriptomic Analysis Identifies that Primary Unloading Globally Shifts Gene Expression and Preserves Mitochondrial Integrity within the Infarct Zone during the Acute Phase of AMI

Background We recently reported that compared to Primary Reperfusion (PR), first reducing myocardial oxygen demand by activating an acute mechanical circulatory support (AMCS) pump while delaying coronary reperfusion (Primary Unloading; PU) reduces myocardial damage in models of acute myocardial inf...

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Veröffentlicht in:Journal of the American College of Cardiology 2016-11, Vol.68 (18), p.B80-B80
Hauptverfasser: Esposito, Michele, Zhang, Yali, Schnitzler, Gavin, Paruchuri, Vikram, Qiao, Xiaoying, Annamalai, Shiva, Mackey, Emily, Morine, Kevin, Mullin, Andrew, Breton, Catalina, Karas, Richard, Josephy, Noam, Kapur, Navin
Format: Artikel
Sprache:eng
Schlagworte:
Cardiology
Cardiovascular
Gene expression
Internal Medicine
Scanning electron microscopy
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Zusammenfassung:Background We recently reported that compared to Primary Reperfusion (PR), first reducing myocardial oxygen demand by activating an acute mechanical circulatory support (AMCS) pump while delaying coronary reperfusion (Primary Unloading; PU) reduces myocardial damage in models of acute myocardial infarction (AMI).
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2016.09.338