NMDA Receptor Antagonist Ketamine Produces Opposing Effects on Resting and Task-Related Brain Activation During Working Memory in Humans

NMDA Receptor Antagonist Ketamine Produces Opposing Effects on Resting and Task-Related Brain Activation During Working Memory in Humans

Introduction Preclinical research suggests that N-methyl-D-aspartic acid (NMDA) glutamate receptor function may be essential to working memory (Seamans and Yang 2004; Gozzi A, Herdon H et al. 2008). For this purpose, functional magnetic resonance imaging was employed during a well-researched spatial...

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Veröffentlicht in:NeuroImage (Orlando, Fla.) Fla.), 2009-07, Vol.47, p.S145-S145
Hauptverfasser: Driesen, N.R., McCarthy, G., Bhagwagar, Z., Calhoun, V.D., D'Souza, D.C., Holub, J.E., Morgan, P.T, Krystal, J.H.
Format: Artikel
Sprache:eng
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Brain research
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Zusammenfassung:Introduction Preclinical research suggests that N-methyl-D-aspartic acid (NMDA) glutamate receptor function may be essential to working memory (Seamans and Yang 2004; Gozzi A, Herdon H et al. 2008). For this purpose, functional magnetic resonance imaging was employed during a well-researched spatial working memory task and ketamine infusion.
ISSN:1053-8119
1095-9572
DOI:10.1016/S1053-8119(09)71458-2