Quantification of Dynamic Changes of Probability Density Function of Diffusion Spectrum Imaging Using Large Deformation Diffeomorphic Metric Mapping

TR/TE = 9100/142 ms, matrix size = 128*128, in-plane resolution = 2.9 mm and thickness = 2.9 mm. To correct for the difference in slice orientation, the null images (images in DSI with b = 0 s/mm2) of D30 were coregistered to that of D180 using the SPM5 package (Wellcome Department of Imaging Neuroscience, London) and the same transformation matrix was applied to all of the DSI images at D30. [...]our results suggest that LDDMM method could be potentially useful in assessing temporal change of fiber structures during development or disease course.